HATU (25g)

Advantages

• High Efficiency: HATU is known for its high coupling yields and efficiency, especially in difficult couplings.
• Stability: Solutions of HATU in DMF are exceptionally stable, making it ideal for use on synthesizers that utilize pre-made solutions of coupling reagents.
• Safety: Unlike some other coupling reagents, HATU does not contain potentially explosive triazole reagents, making it a safer choice.

Applications

• Synthesis of Aurora A Kinase Inhibitors: HATU has been used in the synthesis of inhibitors for Aurora A kinase, a protein involved in cell cycle regulation.
• HPLC Assay: HATU has been used in HPLC assays to determine D- and L-acid enantiomers in human plasma.
• Amide Bond Formation: HATU is commonly used for amide bond formation reactions in peptide synthesis.
• Selective Acylation: HATU has been used as a catalyst for selective acylation reactions.
• Selecocyclization-Oxidation Deselenation Sequence: HATU has been used in this sequence to form complex peptide structures.
• Peptide Coupling: HATU is widely used as a peptide coupling reagent in both solid-phase and solution-phase synthesis.
• Preparation of N-Arylsulfonamide-Linked Peptides: HATU has been used in the solid-phase synthesis of N-arylsulfonamide-linked peptides.