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HBTU (25g)

$700.00

NOTE: May require 2 week lead time. CAS: 94790-37-1

Qty Price
1 $700.00
2 - 4 $630.00
5 - 9 $595.00
10 - 14 $539.00
15 - 19 $518.00
20 + $490.00

Only the lyophilized product is provided. All researchers are assumed to have all necessary supplies to conduct their research, such as reconstitution solution and disinfecting aids to maintain Sterility.

[cuw_fbt]
Description
HBTU (Hexafluorophosphate Benzotriazole Tetramethyl Uronium) is a widely used peptide coupling reagent in solid-phase peptide synthesis. It was introduced in 1978 and is known for its mild activating properties, which help minimize racemization during peptide synthesis. HBTU is commonly used in Fmoc-based solid-phase peptide synthesis protocols due to its high efficiency and stability.

Mechanism

HBTU activates carboxylic acids by forming a stabilized HOBt (Hydroxybenzotriazole) leaving group. The activated intermediate species is attacked by the amine during aminolysis, resulting in the formation of the desired amide bond. This process is crucial in peptide synthesis as it ensures the correct bonding between amino acids.

Advantages

HBTU offers several advantages in peptide synthesis, including:
  • Low Racemization: HBTU is known for its ability to minimize racemization, which is essential in maintaining the correct stereochemistry of peptides.
  • Simple Reaction Conditions: The reaction conditions for HBTU-mediated peptide synthesis are straightforward and easy to control.
  • Short Reaction Time: HBTU reactions are typically fast, which helps reduce the overall synthesis time.
  • High Yields: HBTU is known for its high coupling yields, ensuring that the desired peptides are produced efficiently

Structure

Crystal and solution structure studies have shown that HBTU has an aminium structure rather than a uronium structure. This is important in understanding its reactivity and behavior during peptide synthesis.
No chemical information available.

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