PE 22-28 13mg

PE-22-28 is a synthetic peptide derived from melittin, the principal active component of bee venom. It has garnered significant attention in biochemical research due to its potential implications in various fields.

Structure and Modifications

PE-22-28 is a truncated version of melittin, comprising 7 amino acid residues. Its structural modifications are designed to support the peptide’s stability and functionality while minimizing undesirable characteristics associated with its parent peptide.

Mechanisms of Action

PE-22-28 exerts its therapeutic effects through a combination of mechanisms that are highly dependent on its specific amino acid sequence. It has been shown to inhibit TREK-1 potassium channels, which is believed to contribute to its potential antidepressant properties. Additionally, the peptide has been found to have antimicrobial activity, possibly by interacting with microbial cell membranes and disrupting their integrity.

Potential Applications

PE-22-28 has been explored in various research contexts, including:

• Antimicrobial Research: The peptide’s potential to exhibit a broad spectrum of action against various microbial organisms, including bacteria and fungi, makes it an intriguing candidate for antimicrobial therapies
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• Inflammation: Research suggests that PE-22-28 might possess anti-inflammatory properties, potentially influential in the context of inflammatory conditions
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• Cancer Cells: The peptide has been found to induce apoptosis in cancer cells, possibly by disrupting mitochondrial membranes and inhibiting angiogenesis
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• Infectious Diseases: Given its potential antimicrobial properties, PE-22-28 has been explored in research within the context of infectious diseases, particularly against antibiotic-resistant strains
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• Inflammatory Conditions: The anti-inflammatory action of PE-22-28 may indicate its potential in the context of various inflammatory conditions, such as autoimmune diseases and chronic inflammatory disorders

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Pharmacokinetics and Stability

The pharmacokinetic profile of PE-22-28 is crucial for understanding its potential implications. Modifications in PE-22-28 are designed to support its resistance to enzymatic degradation, possibly prolonging its half-life in the organism.

Conclusion

PE-22-28 is a multifaceted peptide with a range of potential applications in various fields. Its unique structure and mechanisms of action make it an intriguing candidate for further research and development.