PyBOP (250g)

Name: PyBOP (250g) - Polaris Peptides
Price: 450.00 USD
Availability: InStock

$450.00

NOTE: May require 2 week lead time. CAS: 128625-52-5

Only the lyophilized chemical is provided. All researchers are assumed to have all necessary supplies to conduct their research, such as reconstitution solution and disinfecting aids to maintain Sterility.

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Description

PyBOP is a coupling reagent utilized in solid phase peptide synthesis. Unlike uronium-based coupling reagents, PyBOP offers a distinct advantage by avoiding the formation of unwanted guanidine byproducts, even when used in excess. This unique property makes PyBOP particularly well-suited for complex reactions such as fragment condensation and head-to-tail cyclization, where precise control over byproduct formation is crucial.

Coupling with Benzotriazole-1-yloxy-tris-pyrrolidinophosphonium Hexafluorophosphate2

Remove the N-protecting group using standard deprotection protocols.
Dissolve 1.1 equivalents (based on resin substitution) of the protected amino acid in DMF (5 mL/g of resin) and add to the resin.
Add 1.1 equivalents (based on resin substitution) of 1.0 M PyBOP solution and 2.2 equivalents (based on resin substitution) of diisoproplyethylamine (DIPEA). 1.1 equivalents (based on resin substitution) of 0.5 M HOBt solution in DMF can be added to suppress racemization.
Mix for 10-60 minutes until the Kaiser test is negative.

Chemical Info

No chemical information available.

PyBOP (250g)

NOTE: May require 2 week lead time. CAS: 128625-52-5

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PyBOP (250g)

NOTE: May require 2 week lead time. CAS: 128625-52-5

Related Chemicals

Ammonium Acetate (2.5kg)

Polypropylene Centrifuge Tubes (50 mL) 25-pack

HATU (25g)

Trifluoroacetic Acid (TFA) (500g)

Acetonitrile (2L)

HBTU (25g)

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