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PyBOP (250g)

$450.00

NOTE: May require 2 week lead time. CAS: 128625-52-5

Qty Price
1 $450.00
2 - 4 $405.00
5 - 9 $382.50
10 - 14 $346.50
15 - 19 $333.00
20 + $315.00

Only the lyophilized product is provided. All researchers are assumed to have all necessary supplies to conduct their research, such as reconstitution solution and disinfecting aids to maintain Sterility.

[cuw_fbt]
Description
PyBOP is a coupling reagent utilized in solid phase peptide synthesis. Unlike uronium-based coupling reagents, PyBOP offers a distinct advantage by avoiding the formation of unwanted guanidine byproducts, even when used in excess. This unique property makes PyBOP particularly well-suited for complex reactions such as fragment condensation and head-to-tail cyclization, where precise control over byproduct formation is crucial.
Coupling with Benzotriazole-1-yloxy-tris-pyrrolidinophosphonium Hexafluorophosphate2
  1. Remove the N-protecting group using standard deprotection protocols.
  2. Dissolve 1.1 equivalents (based on resin substitution) of the protected amino acid in DMF (5 mL/g of resin) and add to the resin.
  3. Add 1.1 equivalents (based on resin substitution) of 1.0 M PyBOP solution and 2.2 equivalents (based on resin substitution) of diisoproplyethylamine (DIPEA). 1.1 equivalents (based on resin substitution) of 0.5 M HOBt solution in DMF can be added to suppress racemization.
  4. Mix for 10-60 minutes until the Kaiser test is negative.
No chemical information available.

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