SNAP8 10mg (Topical)

SNAP-8 is a naturally derived, non-toxic, non-invasive peptide that has been studied for its potential to reduce facial wrinkles and improve skin appearance. It is an elongation of the hexapeptide ARGIRELINE and is known for its ability to modulate muscle contraction, thereby reducing the formation of lines and wrinkles.

Structure and Modifications

SNAP-8 is an octapeptide composed of glutamyl and heptapeptide amino acids. Its structure allows it to mimic the N-terminal end of SNAP-25, a protein involved in the SNARE complex, which is essential for neurotransmitter release and muscle contraction.

Synthesis and Research

SNAP-8 has been synthesized using various methods, including solid-phase synthesis. Research has shown that it can effectively reduce the depth of wrinkles on the face caused by muscle contraction, especially in the forehead and around the eyes.

Mechanism of Action

SNAP-8 modulates the formation of the SNARE complex involved in muscle stimulation by mimicking SNAP-25. It acts as a competitor of SNAP-25, occupying its place in the SNARE complex, interfering with its formation, and decreasing stability, thereby relaxing muscles. This mechanism is similar to but distinct from that of Botox, which completely blocks SNARE formation.

Applications

SNAP-8 is commonly used in skincare formulations, particularly in serums and creams, where it is applied topically to the face twice daily. It has been shown to reduce the appearance of expression lines and wrinkles by up to 63% in 30 days. Its use is considered a safer, cheaper, and milder alternative to Botulinum Toxin injections.